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目的针对炔雌醇环丙孕酮片结合二甲双胍治疗肥胖多囊卵巢综合征的可行性和有效性进行分析研究。方法随机选择潮州市湘桥区妇幼保健院2013年10月至2014年10月接收的肥胖多囊卵巢综合征患者120例,将其平均分为对照组和观察组。对照组实施炔雌醇环丙孕酮片治疗,观察组实施炔雌醇环丙孕酮片结合二甲双胍治疗,针对两组患者的临床治疗效果、妊娠情况、各指标的变化情况进行观察比较。结果观察组与对照组临床治疗有效率分别为96.67%、78.33%,差异有统计学意义(P<0.05)。观察组妊娠率为80.00%,对照组为55.00%,差异有统计学意义(P<0.05)。观察组治疗后各激素水平的变化优于对照组,差异有统计学意义(P<0.05)。与治疗前比较,治疗后观察组、对照组各激素水平变化差异有统计学意义(P<0.05)。结论在肥胖多囊卵巢综合症治疗中,炔雌醇环丙孕酮片结合二甲双胍的治疗效果显著,安全性高,患者的妊娠率高,具有可行性,可以进行推广应用。
Objective To investigate the feasibility and effectiveness of ethinyl estradiol cyproterone tablets combined with metformin in the treatment of obese polycystic ovary syndrome. Methods 120 cases of obese patients with polycystic ovary syndrome who received from October 2013 to October 2014 in Xiangqiao District Maternal and Child Health Hospital of Chaozhou were randomly selected and divided into control group and observation group randomly. Control group ethinyl estradiol cyproterone tablets treatment, the observation group ethinyl estradiol cyproterone tablets combined with metformin treatment for the two groups of patients with clinical treatment, pregnancy, the changes of the indicators were observed and compared. Results The effective rates of clinical treatment in observation group and control group were 96.67% and 78.33%, respectively, with significant difference (P <0.05). The pregnancy rate was 80.00% in the observation group and 55.00% in the control group, the difference was statistically significant (P <0.05). The changes of the hormones in the observation group were better than those in the control group, the difference was statistically significant (P <0.05). Compared with those before treatment, there were significant differences in the levels of hormones between the observation group and the control group after treatment (P <0.05). Conclusion Ethinylestradiol and cyproterone tablets combined with metformin have significant therapeutic effect, high safety and high pregnancy rate in the treatment of obese patients with polycystic ovary syndrome, which is feasible and can be popularized and applied.