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成纤维细胞是机体广泛存在的一种间质细胞。传统观念认为成纤维细胞主要合成胶原及组织连接成分,以保持器官功能的稳定性,在炎症反应中它只是辅助作用。然而目前越来越多的证据表明成纤维细胞在炎症的发生中起到重要的作用,而且能促进炎症成功消退。通过调控成纤维细胞可以调控炎症的发生及消退过程,故成纤维细胞有可能成为炎症治疗的新靶点。
Fibroblasts are a type of interstitial cells that exist widely in the body. The traditional concept that fibroblasts mainly collagen and tissue composition, in order to maintain the stability of organ function, it is only an ancillary role in the inflammatory response. However, more and more evidences show that fibroblasts play an important role in the occurrence of inflammation and can promote the successful regression of inflammation. By regulating fibroblasts can regulate the occurrence and regression of inflammation, fibroblasts may become a new target for the treatment of inflammation.