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近年来,随着肾小球疾病发病机理和和病理组织学研究的进展,国内外对本病的治疗提出了一些新的观点和方案,也存在一些分歧。本文着重讨论原发性肾小球疾病,也涉及某些继发性肾小球疾病的治疗问题。一、糖皮质激素的应用自Farnsworth首先应用激素治疗肾病综合征以来,已有35年历史,但其机理远非完全清楚。肾小球疾病多系免疫介导性疾病,故最初应用激素是着眼于抑制免疫。在理论上,激素可作用于免疫过程,如引起胸腺、淋巴结、脾脏等淋巴组织的萎缩,大剂量时可抑制吞噬
In recent years, with the pathogenesis of glomerular disease and the progress of histopathology research, some new ideas and solutions have been proposed for the treatment of this disease both at home and abroad, with some differences as well. This article focuses on primary glomerular disease, but also on the treatment of some secondary glomerular diseases. First, the application of glucocorticoids since the first application of hormones Farnsworth nephrotic syndrome has been 35 years of history, but the mechanism is far from fully understood. Glomerular disease multi-line immune-mediated disease, so the initial application of hormones is to focus on immune suppression. In theory, hormones can act on the immune process, such as causing the atrophy of lymphoid tissues such as the thymus, lymph nodes, spleen, and phagocytosis at high doses