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作者对50例无症状的嗜酒男性患者进行了研究,包括对肌力测量、骨骼肌和心肌活检光镜和电镜观察、超声心动图检查、心脏放射核素扫描检查结果的分析,并与相同年龄的健康对照组对照。患者均为门诊病人,平均年龄38.5±1.2岁,酒精摄入量平均每天为24.3±13g(±SEM),平均达16年。这些病人均无临床的或实验方面的营养不良或电解质失调的征象。三角肌肌力测量,21例(42%)患者肌力<20kg,对照组无一例<20kg。患者肌肉活检23例(46%)标本有肌病的组织学表现,其中中型9例,轻型14例;电镜检查显示为非特异性的线粒体异常,线粒体增大和空泡形成,嵴结构破坏,髓磷脂体形成,肌浆网膨胀,肌丝消失,纤维缩小,脂粒数目增多。取自对照组的10份标本均正常。
The authors studied 50 asymptomatic alcoholic male patients, including analysis of muscle force measurements, light and electron microscopic observations of skeletal and myocardial biopsies, echocardiographic and cardiac radionuclide scan findings, and the same Age healthy control group control. Patients were outpatients with an average age of 38.5 ± 1.2 years and alcohol intake averaged 24.3 ± 13g (± SEM) per day for an average of 16 years. None of these patients had any clinical or experimental signs of malnutrition or electrolyte imbalance. Deltoid muscle strength measurement, 21 patients (42%) muscle strength <20kg, no case of control group <20kg. Twenty-three patients (46%) had myopathological findings in muscle biopsy, of which 9 were medium and 14 were light. Electron microscopy showed nonspecific mitochondrial abnormalities, increased mitochondria and vacuolization, destruction of ridge structure, myelin Body formation, sarcoplasmic reticulum swelling, myofilament disappeared, fiber narrowing, increased number of fat particles. Ten samples from the control group were normal.