论文部分内容阅读
目的考察自制的复方薤白滴丸在家兔体内的动态行为，并与复方薤白胶囊剂进行比较。方法家兔单剂量口服给药后，以小檗碱为指标，用 ＨＰＭ法测定在不同时间点的血药浓度。结果复方薤白滴丸的主要药动学参数： Ｃｍａｘ １５４． ３ μｇ／Ｌ，ＭＡＴ７．８ｈ，ＡＵＣ０→∞ｔｗ４２８．０μｇ／Ｌ；复方薤白胶囊的主要药动学参数：Ｃｍａｘ８９．８μｇ／Ｌ，ＭＡＴ１３．８ｈ，ＡＵＣ０→∞３９８．５μｇ／Ｌ。结论复方薤白滴丸较复方薤白胶囊峰浓度高，生物利用度高。
Objective To investigate the dynamic behavior of self-prepared compound Baibai pills in rabbits and compare it with compound Qibai capsules. METHODS: After a single dose of oral administration to rabbits, berberine was used as an index to determine plasma concentrations at different time points using the HPM method. Results The main pharmacokinetic parameters of Fufang Baibai Pills: Cmax 154. 3 μg/L, MAT7.8h, AUC0→∞tw428.0μg/L; the main pharmacokinetic parameters of Compound Qibai Capsule: Cmax89.8μg/L, MAT13.8h, AUC0→∞398.5μg/L. Conclusion Compared with Fufang Baibai Capsule, the compound Fulingbai Dripping Pill has higher peak concentration and higher bioavailability.