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目的:观察中药益脑康胶囊对动脉粥样硬化(AS)基础上急性脑缺血(ACI)SD大鼠血清一氧化氮(NO)、血管内皮生长因子(VEGF)、血小板衍化生长因子-BB(PDGF-BB)含量的影响,以探讨益脑康胶囊防治缺血性中风的可能机制。方法:将体质量(180±20)g SD雄性大鼠随机分为A、B、C、D、E、F(即正常对照组、益脑康预防组、AS模型组、AS+ACI模型组、益脑康治疗组和立普妥治疗组)6组,采用腹腔注射VD3+高脂喂养复制AS模型,内皮素-1在大脑中动脉附近注射法复制ACI模型。B组在造模同时给予益脑康灌胃治疗,其余各组大鼠在模型成功后分别予0.9%氯化钠溶液、益脑康和立普妥灌胃治疗1周,在治疗前后分别测定血清NO、VEGF、PDGF-BB的含量。结果:B组、F组大鼠血清NO含量较D组明显增高(P<0.01,P<0.05)。B组、E组、F组与D组比较,血清VEGF、PDGF-BB水平均明显下降(P<0.01,P<0.05)。结论:益脑康胶囊可通过提高血清NO含量,降低VEGF、PDGF-BB含量发挥防治动脉粥样硬化性急性缺血中风的作用。
OBJECTIVE: To observe the effects of Yinaokang capsule on serum levels of nitric oxide (NO), vascular endothelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB) content in order to explore the possible mechanism of Yinaokang capsule in the prevention and treatment of ischemic stroke. Methods: The male SD rats (180 ± 20 g) were randomly divided into A, B, C, D, E and F groups (normal control group, Yikangkang prevention group, AS model group and AS + ACI model group , Yinaokang treatment group and Lipitor treatment group). The AS model was induced by intraperitoneal injection of VD3 + high fat diet. Endothelin-1 was injected into the middle cerebral artery by ACI injection. Group B was treated with Yinaokang intragastrically at the same time, and the rats in the other groups were treated with 0.9% sodium chloride solution, Yinakang and Lipitor for 1 week after successful model, respectively, before and after treatment Serum NO, VEGF, PDGF-BB content. Results: The contents of serum NO in group B and group F were significantly higher than those in group D (P <0.01, P <0.05). The levels of serum VEGF and PDGF-BB in group B, group E and group F were significantly lower than those in group D (P <0.01, P <0.05). CONCLUSION: YNK can improve the level of serum NO and decrease the contents of VEGF and PDGF-BB in prevention and treatment of atherosclerotic stroke.