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目的探讨肥厚型心肌病(HCM)患者血清脑钠肽(BNP)和心肌肌钙蛋白I(cTnI)的变化及其与室性心律失常发生的关系。方法回顾性分析60例HCM患者临床资料。依据患者血清BNP和cTnI水平,60例患者分为BNP≥200pg/ml(A组,30例)和BNP<200pg/ml(B组,30例)两组或cTnI≥0.04ng/ml(C组,28例)和cTnI<0.04ng/ml(D组,32例)两组。比较室性心律失常发生率的组间差异。结果 A组频发性室性早博(FPVC)和非持续性室性心动过速(NSVT)发生率高于B组(40.0%和26.7%vs.16.7%和6.7%)(P<0.05)。C组FPVC和NSVT发生率高于D组(39.3%和32.1%vs.15.6%和9.4%)(P<0.05)。A、B组或C、D组持续性室性心动过速(SVT)发生率均无统计学差异(10.0%vs.3.3%或10.7%vs.3.1%)(P>0.05)。结论血清BNP和cTnI水平较高的HCM患者FPVC和NSVT发生率增加。
Objective To investigate the changes of serum brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) in patients with hypertrophic cardiomyopathy (HCM) and its relationship with ventricular arrhythmia. Methods The clinical data of 60 HCM patients were retrospectively analyzed. According to the level of serum BNP and cTnI, 60 patients were divided into two groups: BNP≥200pg / ml (A group, 30 cases) and BNP <200pg / ml (B group, 30 cases) or cTnI≥0.04ng / , 28 cases) and cTnI <0.04ng / ml (D group, 32 cases). Compare the differences between groups in the incidence of ventricular arrhythmias. Results The incidence of FPVC and NSVT in group A was higher than that in group B (40.0% vs 26.7% vs.16.7% vs 6.7%, P <0.05) . The incidence of FPVC and NSVT in group C was higher than that in group D (39.3% and 32.1% vs.15.6% and 9.4% respectively) (P <0.05). The incidence of persistent ventricular tachycardia (SVT) in group A, B or C, D had no statistical difference (10.0% vs.3.3% or10.7% vs.3.1%) (P> 0.05). Conclusion The incidences of FPVC and NSVT in HCM patients with high levels of serum BNP and cTnI were increased.