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目的:探讨子宫动脉栓塞术(UAE)治疗子宫肌瘤对月经和卵巢功能的影响。方法:66例子宫肌瘤行UAE后随访3～33个月,观察月经变化,其中15例在preUAE和postUAE3个月,监测血清黄体生成素(LH)、卵泡刺激素(TSH)、泌乳素(PRL)、孕酮(Prog)、雌二醇(E2)等5种性激素变化。结果:47例(81%)UAE后恢复正常月经或明显改善,5例(8.6%)有一过性月经紊乱,3例(5.2%)出现闭经(年龄>45岁)。14例血清5种性激素在preUAE和postUAE变化差异无显著性意义(P>0.05),1例(年龄46岁)5种性激素preUAE处于卵泡期水平,postUAE3月处于绝经期。结论:UAE治疗子宫肌瘤后,大部分患者可恢复正常月经,对卵巢功能影响小,对血清性激素水平无明显影响,但极少数年龄大于45岁者postUAE可出现闭经。
Objective: To investigate the effects of uterine arterial embolization (UAE) on menstruation and ovarian function. Methods: Sixty-six cases of uterine fibroids were followed up for 3 to 33 months after UAE. The changes of menstruation were observed. Among them, 15 cases were treated with preUAE and postUAE for 3 months. The levels of serum LH, FSH, PRL), progesterone (Prog), estradiol (E2) and other five kinds of sex hormones changes. RESULTS: Forty-seven patients (81%) returned to normal menstruation or were significantly improved after UAE, 5 (8.6%) had transient menstrual disorders and 3 (5.2%) had menopause (> 45 years of age). There were no significant differences in the serum levels of 5 sex hormones between preUAE and postUAE (P> 0.05). One case (age 46 years) of 5 sex hormones preUAE was in follicular phase and postUAE3 month was in the hypoxia period. Conclusion: UAE treatment of uterine fibroids, most patients can resume normal menstruation, ovarian function is small, no effect on serum sex hormone levels, but a very small number of people older than 45 years of postUAE may appear amenorrhea.