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目的观察血浆置换在小儿弥散性血管内凝血治疗中的作用。方法选择临床确诊为小儿弥散性血管内凝血的患儿34例,在积极治疗原发病的基础上给予血浆置换治疗,观察血浆置换前后患儿的出血情况,凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、纤维蛋白原(Fib)、抗凝血酶Ⅲ(ATⅢ)及D-二聚体等指标变化。结果通过血浆置换治疗后,34例患儿出血情况减轻,除血小板变化不大外,PT、APTT及Fib明显改善,ATⅢ明显升高,D-二聚体明显降低。结论血浆置换在小儿弥散性血管内凝血的治疗中临床疗效显著。
Objective To observe the role of plasma exchange in the treatment of disseminated intravascular coagulation in children. Methods Thirty-four children with clinically diagnosed disseminated intravascular coagulation in children were enrolled. Plasma exchange was performed on the basis of active treatment of primary disease. The bleeding, prothrombin time (PT) and activation Partial thrombin time (APTT), fibrinogen (Fib), antithrombin Ⅲ (AT Ⅲ) and D-dimer and other indicators change. Results After the plasma exchange therapy, the bleeding in 34 cases was alleviated. The changes of PT, APTT and Fib, ATⅢ, and D-dimer were significantly lower than those without platelet change. Conclusion Plasma exchange in the treatment of diffuse intravascular coagulation in children has a significant clinical effect.