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采用ELISA双抗体夹心法测定35例过敏性紫癜（AP）患儿血清及尿IL-8浓度，其中紫癜性肾炎（APN）19例，另16例未符合紫癜性肾炎的标准（非APN）。结果表明，APN及非APN患儿血清及尿IL-8水平均显著高于正常对照组；APN组尿IL-8显著高于非APN组，APN组尿IL-8与24h尿蛋白定量呈正相关，APN组中9例肾活检示肾小球系膜增生程度与尿IL-8呈显著正相关。提示IL-8参与了过敏性紫癜的致病过程，动态监测尿IL-8水平可作为了解肾脏受累程度的指标。
Serum and urinary IL-8 levels were measured in 35 children with allergic purpura (AP) by ELISA double antibody sandwich method, including 19 cases of purpuric nephritis (APN) and 16 cases of non-purpura nephritis (non-APN). The results showed that serum and urinary IL-8 levels in children with APN and non-APN were significantly higher than those in normal control group; urinary IL-8 in APN group was significantly higher than that in non-APN group In the APN group, 9 cases of renal biopsy showed a significant positive correlation between the degree of mesangial proliferation and urinary IL-8. Prompt IL-8 involved in the pathogenesis of Henoch-Schonlein purpura, dynamic monitoring of urinary IL-8 levels can be used as an indicator of kidney involvement.