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苯酰胺是多聚(腺嘌呤二磷酸核糖)聚合酶的强抑制剂,它阻止 DNA 链断裂的再修复,增加 DNA 损害剂对细胞的致死效应。多聚(腺嘌呤二磷酸核糖)聚合酶集中在细胞核中,它催化烟酰胺腺瞟呤二核苷酸(NAD)形成多聚(腺嘌呤二磷酸核糖);多聚(腺瞟
Benzamide is a potent inhibitor of poly (adenine diphosphate ribose) polymerase, which prevents further repair of DNA strand breaks and increases the lethal effect of DNA damaging agents on cells. Poly (adenine diphosphate ribose) polymerase is concentrated in the nucleus, catalyzing the formation of poly (adenine diphosphate ribose) by nicotinamide adenosine dinucleotide (NAD); poly