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目的:研究老年慢性心力衰竭(CHF)患者不同心功能状态治疗前后B型钠尿肽(BNP)、肿瘤坏死因子-α(TNF-α)、一氧化氮(NO)变化及其之间的关系。方法:对65例CHF患者(其中NYHAⅡ级25例、Ⅲ级19例、Ⅳ级21例)治疗前后测定了BNP、TNF-α和NO水平,同时超声心动图测量左室射血分数(LVEF),并选择27例健康人作为对照。结果:CHF患者BNP、TNF-α和NO含量升高;随着心功能NYHA分级程度的加重,BNP、TNF-α和NO水平逐级升高,并与LVEF呈负相关;常规药物治疗后,心功能改善,各项指标逆转,与治疗前比较差异有统计学意义。结论:CHF患者BNP、TNF-α和NO升高,常规抗心力衰竭治疗能逆转上述指标。
Objective: To investigate the relationship between the changes of B-type natriuretic peptide (BNP), tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in elderly patients with chronic heart failure (CHF) . Methods: The levels of BNP, TNF-α and NO were measured in 65 patients with CHF (NYHA Ⅱ, 19 cases, 21 cases in grade Ⅲ), and the left ventricular ejection fraction (LVEF) was measured by echocardiography. , And select 27 healthy people as the control. Results: The levels of BNP, TNF-α and NO in CHF patients increased. The level of BNP, TNF-α and NO increased gradually with the increase of NYHA classification, and was negatively correlated with LVEF. After treatment with conventional drugs, Heart function improved, the indicators reversed, compared with before treatment was statistically significant. Conclusion: BNP, TNF-α and NO are elevated in CHF patients. The treatment of conventional anti-heart failure can reverse the above indexes.