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我院内科从1988年10月至1992年1月,共收集慢支炎肺气肿患者应用糖皮质激素引起严重副作用病例10例,报告如下。一、临床资料本组男性6例,女性4例。年龄50～79岁,均符合慢支炎阻塞性肺气肿诊断标准。应用药物均是地塞米松,针剂,每支5mg;片剂,每片0.75mg。连续用药时间最长7年,最短2年,平均4年;每日口服服量1.5mg至2.25mg,间日静注量5mg至10mg。引起各种严重副作用有:①类固醇糖尿病4例。表现为口渴,多饮,尿糖阳性,血糖6.5～8.2mmol/L。②严重感染3例。表现为严重肺部感染,霉菌性口腔炎等。③肌萎缩1例。表现为四肢肌萎缩,皮下瘀点,四肢骨疼痛。④类肾上腺皮质功能亢进症9例。有多汗,满月睑,向心性肥胖。⑤激素反跳和依赖现象10例。表现为喘息、肺部哮鸣等
Our hospital from October 1988 to January 1992, were collected in patients with chronic bronchitis emphysema glucocorticoid cases caused serious side effects in 10 cases, the report is as follows. First, clinical data The group of 6 males and 4 females. Age 50 to 79 years old, are in line with chronic bronchitis obstructive emphysema diagnostic criteria. Application of drugs are dexamethasone, injection, each 5mg; tablets, each 0.75mg. Continuous medication for a maximum of 7 years, the shortest 2 years, an average of 4 years; daily oral dose of 1.5mg to 2.25mg, daily intravenous injection of 5mg to 10mg. Caused a variety of serious side effects are: ① 4 cases of steroid diabetes. Show thirst, drink more, urine positive, blood glucose 6.5 ~ 8.2mmol / L. ② serious infection in 3 cases. Serious pulmonary infection, fungal stomatitis and so on. ③ muscle atrophy in 1 case. The performance of limb muscle atrophy, subcutaneous petechia, limb pain. ④ class of adrenal cortex hyperthyroidism in 9 cases. How sweat, full moon eyelid, concentric obesity. ⑤ hormone rebound and dependence on the phenomenon of 10 cases. Show wheezing, lungs and other wheeze