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自从1974年开始在冠心病患者试用阿司匹林以来,已有6项较大的对照试验显示阿司匹林能减少心肌梗塞后患者的死亡率和梗塞复发率,但均未达到统计学上的显著意义。作者选用不稳定型心绞痛作为阿司匹林二级预防的对象,因为其具有较高急性心肌梗塞和死亡的危险,冠状动脉血流的限制属暂时性、潜在可逆性。本文报道随机双盲安慰剂对照试验的初步结果。方法:1,266例入院前一个月直至入院前一周仍有不稳定型心绞痛的冠心病患者,心电图和酶测定显示无急性心肌梗塞。随机分为两组。阿司匹林组每天服用含有阿司匹林324毫克的发泡缓冲粉剂,安慰剂组则服用不含阿司匹林的发泡缓冲粉剂,
Six large controlled trials of aspirin have been shown to reduce mortality and infarct recurrence rates after myocardial infarction in 1974, but none of them reached statistical significance. The authors chose unstable angina for aspirin secondary prophylaxis because of the high risk of acute myocardial infarction and death, and the limitation of coronary blood flow is transient and potentially reversible. This article reports the preliminary results of a randomized, double-blind, placebo-controlled trial. METHODS: A total of 1,266 patients with coronary heart disease who had unstable angina pectoris one month prior to admission to hospital one week before admission, electrocardiogram and enzyme measurements showed no acute myocardial infarction. Randomly divided into two groups. The aspirin group took 324 mg of aspirin foaming buffered powder daily, the placebo group took aspirin-free foaming buffered powder,