甲酰肽受体在炎症和感染中的作用

来源 :国际免疫学杂志 | 被引量 : 0次 | 上传用户:pengxiubin
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
甲酰肽受体(Formyl-peptide receptors, FPRs)属于G蛋白偶联受体家族,具有模式识别受体(pattern recognizing receptor, PRR)特性,能够识别病原体和宿主来源的配体,介导炎性细胞的趋化和炎症介质的释放,在天然免疫和炎症反应中发挥重要作用。研究发现FPRs不仅高表达于多种炎性细胞,在组织细胞也有表达,且与不同的配体结合产生不同的效应,参与机体稳态维持,是很多疾病治疗的潜在靶标。文章综述了近几年来FPRs在炎症发生发展和感染中的作用以及其调控机制的研究进展。“,”Formyl-peptide receptors (FPRs) belong to the G protein-coupled receptor family, and have the characteristics of pattern recognizing receptor (PRR) , which can recognize ligands from pathogens and hosts, mediate the chemotaxis of inflammatory cells and release of inflammatory mediators, and play an important role in natural immunity and inflammatory response. Studies show that FPRs are not only highly expressed on cells related to inflammation, but also on histiocytes, and take different biological effects by binding with different ligands, participating in the maintenance of homeostasis. They are considered as potential targets for treatment of many diseases. In this paper, the role of FPRs in the occurrence, development and infection of inflammation and its regulatory mechanism in recent years are reviewed.
其他文献
  Background: Informant is essential for data collection for the subject in psychological autopsy, but how the characteristics of informant effect on the vali
会议
鸡西矿业集团公司张辰煤矿西三采区3
期刊
前言众所周知,人们一般用扬声器的频率响应曲线和相位响应曲线来描述扬声器的电声性能。而测量扬声器的频率响应曲线和相位响应曲线,不仅需要一条特定的音频测量仪器,而且必
国家实施的西部大开发战略与加大财政政策力度,将意味着一大批国有大型基础设施建设项目的上马。为了防止建设项目投资超支、工程质量低劣、建设进度拖延,国家实施了项目业主或
在哲学上,康德“判断力”是指以某种形式将不同的表象或概念联接在一起,也就是综合,而这一“判断力”论述对翻译过程有着重要的启示.
宫颈癌是全球女性常见的恶性肿瘤之一,其占女性新增癌症患者的9%(529 800),癌症死亡总数的8%(275 100)[1]。宫颈癌晚期死亡的主要原因之一就是癌细胞的浸润和转移。肿瘤细胞
  Much of what is currently known about suicide survivor responses and outcomes in the aftermath of a significant others completed suicide is based on the res
会议
  Background: About 60% of suicide deceased victims did not contact with mental health services before they died.They were found to have high level of suicide
会议
[摘 要] 小电流接地系统即中性点不直接接地系统,主要解决在小电流接地系统中发生单相接地时的故障测距问题。由于单相接地时的暂态分量往往比稳态分量大几倍到几十倍,容易测量,且消弧线圈相当于开路,对暂态分量几乎没有影响,因而选用一种适合分析暂态信号的方法将有助于提高選线的正确率。  [关键词] 小波变换 单相接地 中性点
今日投资独家发布2010年12月份基金经理调查95%的基金经理判断2011年A股市场的投资回报为正,机构投资者逢低买入意愿增强,逢高减持意愿下降。 Today’s investment exclusiv