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目的了解延安市恶性肿瘤患者弓形虫感染概况,探讨两者相关性。方法采用酶联免疫吸附实验(ELISA)间接法对120例不同类型的恶性肿瘤患者和80名正常体检者进行AtAb检测。结果研究组病人抗弓形虫抗体(AtAb)免疫吸附实验的阳性率为16.67%(20/120),与健康对照组AtAb的阳性率6.25%(5/80)比较,两组间差异有统计学意义(χ2=4.76,P<0.05)。不同系统恶性肿瘤患者AtAb的阳性率略有不同,其中消化系统为18.75%(9/48),呼吸系统为15.00%(3/20),生殖系统为16.67%(6/36),其它系统为12.50%(2/16),但各系统恶性肿瘤患者AtAb的阳性率比较,无有统计学意义(χ2=6.00,P>0.05)。不同性别恶性肿瘤AtAb的阳性率也不同,其中男性为19.64%(11/56),女性为14.06%(9/64),但两者间差异无有统计学意义(χ2=0.67,P>0.05)。结论免疫功能低下的恶性肿瘤患者容易感染弓形虫或促使潜伏的弓形虫活动,应引起医务人员的足够重视。
Objective To understand the general situation of Toxoplasma gondii infection in patients with malignant tumor in Yan’an and to explore the correlation between them. Methods AtAb was detected in 120 patients with different types of malignant tumors and 80 normal controls by enzyme-linked immunosorbent assay (ELISA). Results The positive rate of AtAb immunosorbent assay was 16.67% (20/120) in the study group, compared with 6.25% (5/80) in the healthy control group, the difference was statistically significant between the two groups Significance (χ2 = 4.76, P <0.05). The positive rates of AtAb in patients with different malignancies were slightly different, including 18.75% (9/48) in digestive system, 15.00% (3/20) in respiratory system and 16.67% (6/36) in reproductive system. Other systems were 12.50% (2/16) respectively. However, there was no significant difference in the positive rate of AtAb among malignant tumor patients (χ2 = 6.00, P> 0.05). The positive rates of AtAb in different malignant tumors were also different, including 19.64% (11/56) in males and 14.06% (9/64) in females, but the difference was not statistically significant (χ2 = 0.67, P> 0.05 ). Conclusion Immunocompromised patients with Toxoplasma gondii susceptible to infection or to promote the potential of Toxoplasma gondii, should arouse sufficient attention of medical personnel.