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目的:探讨血管内皮生长因子(VEGF)在原发性肝癌组织中的表达及其与肿癌的浸润转移的关系。方法:采用SP免疫组化法,检测60例原发性肝癌标本、30例癌旁组织和30例正常组织中VEGF的表达。结果:肝癌组的VEGF阳性表达率为68.3%,显著高于癌旁组(40.0%)和正常对照组(33.3%),有统计学差异(P<0.05);包膜不完整组织中VEGF阳性表达为92.9%,显著高于包膜完整组织(P<0.05);远处转移组织中VEGF阳性表达率为96.6%,显著高于无转移组织(P<0.05);而VEGF阳性表达在不同的TNM分期之间、肿瘤分化程度之间以及不同的病灶大小之间差异无统计学意义(P>0.05)。结论:VEGF在原发性肝癌组织中呈高表达,VEGF表达与肿瘤包膜有无和是否发生远处转移有关,VEGF在肝癌血管生成、生长及转移中起重要作用。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in primary hepatocellular carcinoma (HCC) and its relationship with invasion and metastasis of tumor. Methods: SP immunohistochemical method was used to detect the expression of VEGF in 60 cases of primary hepatocellular carcinoma, 30 cases of paracancerous tissues and 30 cases of normal tissues. Results: The positive rate of VEGF expression in hepatocellular carcinoma was 68.3%, which was significantly higher than that in adjacent normal tissue (40.0%) and normal control group (33.3%) (P <0.05) (92.9%), which was significantly higher than that in intact enamel (P <0.05). The positive expression rate of VEGF in distant metastasis was 96.6%, which was significantly higher than that in non-metastatic tissue (P <0.05) There was no significant difference between TNM stage, tumor differentiation degree and different lesion size (P> 0.05). Conclusion: The expression of VEGF is highly expressed in primary hepatocellular carcinoma. The expression of VEGF is correlated with the presence or absence of tumor capsule and distant metastasis. VEGF plays an important role in angiogenesis, growth and metastasis of hepatocellular carcinoma.