PrP~(Sc)是朊毒体(prion)的一种特殊构象,仅在朊毒体引起的哺乳动物传染病中发现。正常情况下,PrP在细胞内质网(ER)成熟时会发生错误折叠,这些构象改变的PrP不能运至胞膜而逆向转运至胞液,由蛋白酶消化降解;若抑制蛋白酶活性,PrP就会堆积在胞液中,部分PrP就会转变为PrP~(Sc)。本文通过抑制蛋白酶活性使PrP在胞液中堆积以提高 PrP ~ (Sc) is a special conformation of the prion that is only found in mammalian infectious diseases caused by prion. Under normal circumstances, PrP misfolded when the endoplasmic reticulum (ER) matures. These conformationally-modified PrPs can not be delivered to the membrane but transported back to the cytosol and degraded by protease digestion. If the protease activity is inhibited, PrP will Accumulation in the cytosol, part of the PrP will be converted to PrP ~ (Sc). This article by inhibiting the protease activity of PrP accumulation in the cytosol to increase