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目的探讨腱鞘纤维瘤(FTS)临床病理学特征、免疫表型及鉴别诊断要点。方法对3例发生于肌腱附近的FTS进行光镜观察和免疫组化标记并文献复习。结果FTS好发于成人,右侧手掌和腕部多见,临床表现多为小的质硬、无痛性和缓慢增大的肿块。病变界限清楚,呈多结节状。典型病变由稀疏散在的纤维母细胞、狭窄的血管腔隙和大量致密的胶原纤维组成,细胞异型性小,无核分裂象。免疫组化:vimentin(+);α-SMA和MSA弱(+),少量细胞CD68(+)。结论FTS是一种不常见的位于肌腱附近的良性纤维性小结节,病变无浸润性且从不转移,故切除的目的应为减轻症状、保留功能。
Objective To investigate the clinicopathological features, immunophenotypes and differential diagnosis of tendon sheath fibroma (FTS). Methods Three cases of FTS occurred near the tendon were observed by light microscopy and immunohistochemically marked and reviewed. Results FTS occurs in adults, the right hand and wrist more common clinical features and more for the small hard, painless and slowly increasing mass. Clear boundaries of the disease, was multi-nodular. Typical lesions from sparse scattered fibroblasts, narrow vascular lacuna and a large number of dense collagen fibers, cell atypia, mitotic. Immunohistochemistry: vimentin (+); α-SMA and MSA weak (+), a small amount of cells CD68 (+). Conclusion FTS is an uncommon benign fibrous nodules located near the tendon. The lesions are non-invasive and never metastable. Therefore, the purpose of resection should be to relieve the symptoms and preserve the function.