论文部分内容阅读
目的探讨CD4+T细胞内细胞因子在视神经脊髓炎及其临床分期中的特点及变化。方法对视神经脊髓炎和健康对照的末梢血中CD4+T细胞内的细胞因子染色并利用流式细胞仪进行测定和分析。结果与健康对照比较视神经脊髓炎CD4+IFNγ+IL4-细胞在复发期和缓解期均显著增加。结论视神经脊髓炎是以I型辅助性T细胞的反应占优势,在其复发期和缓解期这种反应的优势均明显提高。同时也说明利用流式细胞仪对T细胞亚型进行测定在神经系统自身免疫性疾病的分析过程中有一定的参考价值。
Objective To investigate the characteristics and changes of cytokines in CD4 + T cells in optic neuromyelitis and its clinical stage. Methods Cytokines in CD4 + T cells in peripheral blood of optic neuromyelitis and healthy controls were stained and analyzed by flow cytometry. Results Compared with healthy controls, optic nerve myelitis CD4 + IFNγ + IL4- cells were significantly increased in relapse and remission. Conclusions Optic neuromyelitis is predominantly type I helper T cells, and the advantages of this response are both significantly improved during its relapse and remission. It also shows that the use of flow cytometry T cell subtypes in the analysis of the nervous system autoimmune diseases have some reference value.