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应用锡类散和甲氰咪胍治疗了25例经内窥镜确诊的活动性十二指肠球溃疡患者。分别在疗前及疗后3周取溃疡旁活检组织进行HE、AB(pH2.5)、PAS和AB(pH2.5)-PAS染色。根据形态学特点,将其分为肠型、胃型及过渡型上皮。并测量游离腔面细胞密度及长度百分比。结果:溃疡愈合早期(3周),杯状细胞的恢复主要出现在溃疡旁上皮;可见到较多移行上皮。两组形态学变化无明显差异。根据内窥镜观察,溃疡愈合后仍有胃型粘膜及移行上皮存在。在大多数肠绒毛还可发现胃化生粘膜。并对上述机制进行了探讨。
Twenty-five patients with active duodenal ulcer diagnosed by endoscopy were treated with tin-based dispersions and cimetidine. The biopsy tissues of ulcer were taken before and 3 weeks after treatment respectively for HE, AB (pH2.5), PAS and AB (pH2.5) -PAS staining. According to morphological characteristics, divided into intestinal type, gastric type and transitional epithelium. And measure the density and length of free cell surface area percentage. Results: In the early stage of ulcer healing (3 weeks), the goblet cells recovered mainly in the paracancer epithelium; more transitional epithelium was seen. There was no significant difference in morphology between the two groups. According to the endoscopic observation, gastric mucosa and transitional epithelium still exist after ulcer healing. Gastric mucosa can also be found in most villi. And discussed the above mechanism.