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体外培养试验证明,吡喹酮对细粒棘球蚴原头节(以下简称原头节)具有较强的杀灭作用,而阿苯达唑的则较差和缓慢。本文系报道用透射电镜观察此2种药物对原头节超微结构的影响。结果表明,体外培养的原头节经吡喹酮1μg/ml作用1h即见少数原头节的皮层细胞核染色质有集聚,胞浆内有空泡变化;集合管扩
In vitro culture experiments showed that praziquantel has a strong killing effect on the protoscoid Echinococcus granulosus (hereinafter referred to as the original head section), while albendazole is poor and slow. This article reports the use of transmission electron microscopy to observe the effects of these two drugs on the ultrastructure of prorocelum. The results showed that the protoscoleces cultured in vitro were treated with 1μg / ml praziquantel for 1h, and the chromatin in the cortical nuclei of some primate nodules accumulated and vacuoles changed in the cytoplasm.