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目的 探讨肾细胞癌 (RCC)中p2 7的表达与肾癌细胞增殖的关系。方法 采用鼠抗人p2 7单克隆抗体及Ki- 6 7抗原单克隆抗体对 86例肾细胞癌和 86例癌旁组织进行免疫组化染色。结果 RCC中p2 7表达明显减少 ,Ki- 6 7指数 (Ki- 6 7LI)明显增高 ;且p2 7表达与Ki- 6 7指数 (Ki- 6 7LI)在肿瘤病理分级、临床分期和淋巴结转移方面呈负相关。结论 p2 7和Ki - 6 7LI从细胞生长抑制和增殖活性两个不同的侧面反映了肿瘤细胞的侵润能力 ,联合检测p2 7和Ki- 6 7LI对预测肾癌的的生物学行为及预后具有重要的意义。
Objective To investigate the relationship between the expression of p27 and the proliferation of renal cell carcinoma (RCC) in renal cell carcinoma (RCC). Methods Immunohistochemical staining was performed on 86 cases of renal cell carcinoma and 86 cases of paracancerous tissues using mouse anti-human p2 7 monoclonal antibody and Ki- Results The expression of p27 in RCC was significantly decreased and the Ki- 6 7 index (Ki- 6 7LI) was significantly increased. The expression of p27 and Ki- 67 index in the pathological grading, clinical stage and lymph node metastasis Negative correlation. Conclusions Both p27 and Ki - 67LI can reflect the invasion ability of tumor cells from two different sides of cell growth inhibition and proliferation activity. The combined detection of p27 and Ki67L has the predictive value for the biological behavior and prognosis of renal cell carcinoma Significance.