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目的探讨鼻咽癌放疗配合羟基喜树碱化疗的近期疗效。方法148例经病理证实的鼻咽癌,随机分为放化疗组76例,放疗组72例。两组均行常规放疗:鼻咽癌原发灶DT:68～74Gy,颈部肿物DT:65～75Gy。放化疗组配合应用羟基喜树碱10mg/d,1次/周。结果两组完全缓解率放化疗组为76.3%,单纯放疗组55.0%,两组比较差异有统计学意义(P<0.01),颈部肿物平均消退时间为:放化疗组N1(22.4±1.1)d、N2(30.4±1.6)d、N3(43.7±2.3)d,而放疗组为N1(33.6±3.6)d、N2(49.9±5.4)d,N3(56.3±6.76)d,放化疗组肿物消退时间快于放疗组(P<0.01),而且两组副作用差异不大。结论鼻咽癌放射治疗配合使用羟基喜树碱化疗能缩短颈部肿物消退时间,从而提高局部控制率及完全缓解率,增加治疗的效果。
Objective To investigate the short-term curative effect of nasopharyngeal carcinoma radiotherapy with hydroxy camptothecin chemotherapy. Methods 148 cases of nasopharyngeal carcinoma confirmed by pathology were randomly divided into radiotherapy and chemotherapy group of 76 cases and radiotherapy group of 72 cases. Both groups underwent conventional radiotherapy: primary tumor of nasopharyngeal carcinoma DT: 68 ~ 74Gy, neck mass DT: 65 ~ 75Gy. Radiotherapy and chemotherapy group with the application of hydroxycamptothecin 10mg / d, 1 / week. Results The complete remission rate of the two groups was 76.3% in the radiotherapy and chemotherapy group and 55.0% in the radiotherapy group. The difference between the two groups was statistically significant (P <0.01) ), N2 (30.4 ± 1.6) d and N3 (43.7 ± 2.3) d respectively, while the radiotherapy group was N1 (33.6 ± 3.6) d, N2 The tumor subsided faster than the radiotherapy group (P <0.01), and there was no significant difference between the two groups. Conclusion Radiotherapy of nasopharyngeal carcinoma combined with hydroxycamptothecin chemotherapy can shorten the neck mass remission time, thereby enhancing the local control and complete remission rate and increase the effect of treatment.