野生型P53基因产物的高度表达能抑制原代大鼠胚胎纤维母细胞的恶性转化。早期报导P53癌基因是一种突变型的基因。在许多人类恶性肿瘤中都发现有P53基因的突变。突变的P53蛋白能通过与野生型蛋白形成异源性二聚体而灭活。野生型P53蛋白的半衰期大约20分钟,但在DNA肿瘤病毒感染的细胞中可延长至2～24小时。因此,在大多数肿瘤细胞内,可检测到野生型P53蛋白的存在,可能表示这 The high expression of wild-type P53 gene product can inhibit the malignant transformation of primary rat embryonic fibroblasts. Early reports that the P53 oncogene is a mutant gene. Mutations in the P53 gene have been found in many human malignancies. The mutated P53 protein can be inactivated by forming a heterodimer with a wild-type protein. The half-life of the wild-type P53 protein is approximately 20 minutes, but can be extended to 2 to 24 hours in DNA tumor virus-infected cells. Therefore, the presence of wild-type P53 protein can be detected in most tumor cells, which may indicate this