论文部分内容阅读
采用免疫组织化学 Ａ Ｂ Ｃ 法，测定了４０ 例胆囊癌和８ 例胆囊腺瘤性息肉组织中 Ｐ２１ 、 Ｐ５３ 、 Ｂ Ｃ Ｌ－ ２ 癌基因蛋白的表达情况及增殖细胞核抗原的表达强度．结果显示： Ｐ２１ 、 Ｐ５３ 、 Ｂ Ｃ Ｌ－２ 蛋白阳性表达率在胆囊癌组织中分别为５２ ．５ ％ 、５２ ．５ ％ 和７０ ％ ．在胆囊腺瘤性息肉中分别为０ ％ 、０ ％ 和１００ ％ ．提示：检测 Ｐ２１ 、 Ｐ５３ 、 Ｂ Ｃ Ｌ－ ２ 蛋白表达情况对胆囊癌与胆囊腺瘤性息肉的鉴别诊断有一定意义； Ｐ２１ 、 Ｐ５３ 蛋白表达可能是胆囊癌预后不良的重要指标
Using immunohistochemical A B C method, the expression of P21, P53 and B C L-2 oncogene proteins and the expression of proliferating cell nuclear antigen in 40 cases of gallbladder carcinoma and 8 cases of gallbladder adenoma polyp were measured. The results showed that the positive expression rates of P21, P53 and B C L-2 proteins were 52 in gallbladder cancer tissues, respectively. 5 %, 52. 5 % and 70 % . In gallbladder adenomatous polyps were 0 %, 0 % and 100 %, respectively. Tip: The detection of P21, P53 and B C L-2 protein expression has certain significance in the differential diagnosis of gallbladder carcinoma and gallbladder adenomatous polyp; P21, P53 protein expression may be an important indicator of poor prognosis of gallbladder carcinoma.