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目的:观察“三仙”不同炮制品对实验大鼠胃酸、胃液、胃蛋白酶分泌的影响。方法:实验大鼠末次灌胃后采用大鼠幽门结扎法造模,3h后观察各组大鼠胃液、胃酸、胃蛋白酶分泌的变化。结果:和空白组相比,养胃舒颗粒组的胃液量增加(P<0.05),生品的中剂量组胃液分泌量增加(P<0.05);养胃舒颗粒组的胃酸(PH)降低(P<0.05),生品的中剂量组胃酸(PH)明显降低(P<0.05);养胃舒颗粒的胃蛋白酶活性升高(P<0.05),生品的中剂量组胃蛋白酶活性显著升高(P<0.01),生品的低剂量组胃蛋白酶活性升高(P<0.05)。结论:三仙的生品具有促进大鼠胃酸分泌、增加胃液分泌量、促进胃蛋白酶活性的作用。
Objective: To observe the effect of different processed products of “Sanxian” on gastric acid, gastric juice and pepsin secretion in experimental rats. Methods: The rats in the experimental group were given gastric pyloric ligation after the last time of gavage, and the changes of gastric juice, gastric acid and pepsin in rats were observed after 3 hours. Results: Compared with the blank group, the volume of gastric juice in Yangweishu granule group increased (P <0.05), the amount of gastric juice in medium dose group increased (P <0.05), and the gastric acid (PH) (P <0.05). The gastric acid (PH) of the middle-dose group was significantly lower (P <0.05), the activity of pepsin of Yangweishu granule was increased (P <0.05), and the pepsin activity of the medium-dose group was significantly higher (P <0.01). The activity of pepsin in the low dose group of raw product increased (P <0.05). Conclusion: San Xian ’s raw products can promote gastric acid secretion, increase gastric juice secretion and promote pepsin activity.