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已报道,在肝脏疾病、恶性病变和其它疾病时血清分泌性IgA水平均增加。肝脏疾病血清分泌性Ig A增加的原因是从胆汁中返流至血清,和/或游离分泌性成分从肝胆组织中直接释放,和/或胆汁进入血清。一些研究者报道,在恶性病变,尤其是有肝转移时分泌性IgA水平增加。采用免疫组织化学方法在结肠癌、乳腺癌和胃癌患者中发现了分泌性成分或IgA。然而,在有或无肝转移恶性病变患者中分泌性IgA增加的原因至今尚不清楚。作者测定了胃癌患者血浆分泌性IgA的水平。60例胃癌病人血浆分泌性IgA的水平(9.6±
Serum secretory IgA levels have been reported to increase in liver diseases, malignant lesions and other diseases. The increase in serum secretory IgA in liver disease is due to reflux from the bile to the serum, and/or the release of free secretory components from the hepatobiliary tissue, and/or bile into the serum. Some investigators have reported increased levels of secretory IgA in malignant lesions, especially liver metastases. Secretory components or IgA were found in patients with colon, breast, and gastric cancer using immunohistochemistry. However, the cause of the increase in secretory IgA in patients with or without hepatic metastatic malignancy remains unclear. The authors measured plasma secretory IgA levels in gastric cancer patients. Serum secretory IgA levels in 60 patients with gastric cancer (9.6±