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应用双抗体夹心法测定１１３例Ⅰ～Ⅳ级脑胶质瘤患者手术前后血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平。结果发现胶质瘤患者术前血清ｓＩＬ－２Ｒ均高于正常对照组，其升高程度与肿瘤分级有明显关系（Ｐ＜０．０１），术后ｓＩＬ－２Ｒ均有不同程度下降，其中Ⅱ～Ⅳ级者下降尤为明显（Ｐ＜０．０１）；术后ｓＩＬ－２Ｒ再次升高可先于肿瘤复发；血清ｓＩＬ－２Ｒ与脑脊液（ＣＳＦ）及肿瘤囊液中ｓＩＬ－２Ｒ均呈正相关。提示血清ｓＩＬ－２Ｒ的检测，对推测肿瘤恶性程度及预测肿瘤复发有一定意义。
The level of serum soluble interleukin 2 receptor (sIL-2R) in 113 patients with grade I-IV glioma before and after operation was measured by double antibody sandwich method. The results showed that preoperative serum sIL-2R levels in glioma patients were higher than those in the normal control group, and the increase was significantly related to tumor grade (P<0.01). Postoperative sIL-2R decreased to varying degrees, including II. The decline was particularly significant in patients with grade IV to grade IV (P<0.01). The re-elevation of sIL-2R after surgery may precede tumor recurrence; serum sIL-2R was positively correlated with cSF and sIL-2R in tumor cysts. The detection of serum sIL-2R suggests a certain significance for estimating the degree of malignancy and predicting tumor recurrence.