论文部分内容阅读
目的探讨经皮冠状动脉介入术(percutaneous coronary intervention,PCI)后发生支架内再狭窄的相关危险因素。方法回顾性分析235例行PCI术患者的临床资料,术后1a发生支架内再狭窄55例为观察组,未发生支架内再狭窄180例为对照组,比较2组一般资料,采用多因素logistic回归分析发生支架内再狭窄的危险因素。结果观察组年龄[(65.9±10.0)岁]较对照组[(60.3±10.9)岁]大(P<0.05),尿酸[(484.16±84.04)mmol/L]、肌酐[(84.36±28.19)μmol/L]、高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)[(5.49±3.62)mmol/L]水平均高于对照组[(323.11±92.30)mmol/L、(75.81±24.78)μmol/L、(2.15±1.86)mmol/L](P<0.05);多因素logistic回归分析结果显示,高龄(OR=1.104,95%CI:1.043~1.168,P=0.001)、PCI术前高尿酸水平(OR=8.431,95%CI:4.035~17.620,P=0.000)、高hs-CRP水平(OR=2.016,95%CI:1.519~2.674,P=0.000)是PCI术后1a发生支架内再狭窄的危险因素。结论高龄,PCI术前高尿酸、高hs-CRP水平是冠心病行PCI术患者术后1a发生支架内再狭窄的危险因素。
Objective To investigate the risk factors of in-stent restenosis after percutaneous coronary intervention (PCI). Methods The clinical data of 235 patients undergoing PCI were analyzed retrospectively. 55 cases of in-stent restenosis after operation were selected as observation group and 180 cases of in-stent restenosis as control group. The general data of two groups were compared. Multivariate logistic regression Regression analysis of risk factors for in-stent restenosis. Results The age of the observation group was significantly higher than that of the control group [(65.9 ± 10.0) years vs [60.3 ± 10.9 years] (P <0.05), uric acid (484.16 ± 84.04) mmol / L and creatinine [(84.36 ± 28.19) / L] and hs-CRP [(5.49 ± 3.62) mmol / L] were significantly higher than those in the control group [(323.11 ± 92.30) mmol / L, (75.81 ± 24.78 (OR = 1.104, 95% CI: 1.043 ~ 1.168, P = 0.001), and before PCI High uric acid levels (OR = 8.431, 95% CI: 4.035-17.620, P = 0.000) and high hs-CRP levels (OR = 2.016,95% CI 1.519-2.674, P = 0.000) Risk factors for restenosis. Conclusion The elderly patients with hyperuricemia and high hs-CRP level before PCI are the risk factors for in-stent restenosis after PCI in patients with coronary artery disease.