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目的:为寻找新的有效抗疟药物提供实验依据。方法:建立伯氏疟原虫鼠疟实验模型,比较常山复方、金牛草、山豆根、鹅不食草、常山、仙鹤草、青蒿等药物的50%醇提取物抗疟活性,比较抗疟活性最强醇提取物中不同萃取部位对疟原虫的抑制效果。结果:常山复方的50%醇提取物疟原虫抑制率为83.46%,高于青蒿药材的67.33%,抗疟效果比较差异具有统计学意义(P<0.05);常山复方的50%醇提取物乙酸乙酯萃取部位对疟原虫的抑制率达93.78%,与青蒿素的95.92%接近。结论:常山复方乙酸乙酯萃取物具有显著的抗疟活性,可作为抗击疟疾的候选药物。
Objective: To provide experimental evidence for finding new and effective antimalarial drugs. Methods: The experimental model of Plasmodium berghei was established. The anti-malarial activity of 50% alcohol extract of Changshan Compound, Jinniucao, Shandougan, Goose not herbivore, Changshan, Agrimony, Artemisia annua and other drugs were compared. Inhibitory effect of different extraction sites on Plasmodium in the most active alcohol extract. Results: The inhibitory rate of 50% alcohol extract of Changshan Compound to Plasmodium was 83.46%, higher than 67.33% of that of Artemisia annua L. The difference of antimalarial effect was statistically significant (P <0.05) The inhibitory rate of ethyl acetate extract on Plasmodium reached 93.78%, which was close to 95.92% of artemisinin. Conclusion: Changshan Compound ethyl acetate extract has significant anti-malarial activity and can be used as a candidate drug to combat malaria.