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目的：比较两种不同的 Ａ Ｔ Ｐ敏感性钾通道开放剂 Ｋ Ｒ Ｎ２３９１（ Ｋ Ｒ Ｎ）和克罗卡林（ Ｃ Ｒ）对大鼠离体心脏心功能的影响及缺血后的心脏保护作用。方法：将离体心脏进行完全缺血 ２５ ｍ ｉｎ，观察再灌注３０ ｍ ｉｎ 时心功能的变化。结果：１～２０ μｍ ｏｌ／ Ｌ Ｋ Ｒ Ｎ 及１～２０ μｍ ｏｌ／ Ｌ Ｃ Ｒ均能显著增加冠脉灌流量。２０ μｍ ｏｌ／ Ｌ Ｋ Ｒ Ｎ 及 １０ μｍ ｏｌ／ Ｌ Ｃ Ｒ 可明显降低心脏收缩功能，１ μｍ ｏｌ／ Ｌ Ｋ Ｒ Ｎ 和１ μｍ ｏｌ／ Ｌ Ｃ Ｒ较对照组均有改善缺血后心功能的作用，此作用可完全被格列本脲所阻断。结论：两药均有明显冠脉扩张作用，大剂量应用可降低心脏收缩功能，用不影响心功能的剂量两者均有对缺血后心脏的保护作用，此作用与 Ａ Ｔ Ｐ敏感性钾通道开放有关。
OBJECTIVE: To compare the effects of two different A T P-sensitive potassium channel openers K R N2391 (K R N) and crokalin (C R) on isolated rat heart function and ischemic cardioprotection effect. Methods: The isolated hearts were subjected to complete ischemia for 25 minutes and the changes of cardiac function were observed at 30 minutes of reperfusion. Results: 1 ~ 20 μmol / L K R N and 1 ~ 20 μmol / L C R all significantly increased coronary perfusion. 20 μmol / L K R N and 10 μm ol / L C R significantly reduced cardiac contractile function, while 1 μmol / L K R N and 1 μmol / L C R both improved myocardial function after ischemia The role of this effect can be completely blocked by glyburide. Conclusion: The two drugs have obvious coronary dilatation, high-dose application can reduce cardiac contractile function, with no effect on cardiac function of both have a protective effect on the ischemic heart, this role with the A T P-sensitive potassium Channel open related.