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目的:比较两种不同的 A T P敏感性钾通道开放剂 K R N2391( K R N)和克罗卡林( C R)对大鼠离体心脏心功能的影响及缺血后的心脏保护作用。方法:将离体心脏进行完全缺血 25 m in,观察再灌注30 m in 时心功能的变化。结果:1~20 μm ol/ L K R N 及1~20 μm ol/ L C R均能显著增加冠脉灌流量。20 μm ol/ L K R N 及 10 μm ol/ L C R 可明显降低心脏收缩功能,1 μm ol/ L K R N 和1 μm ol/ L C R较对照组均有改善缺血后心功能的作用,此作用可完全被格列本脲所阻断。结论:两药均有明显冠脉扩张作用,大剂量应用可降低心脏收缩功能,用不影响心功能的剂量两者均有对缺血后心脏的保护作用,此作用与 A T P敏感性钾通道开放有关。
OBJECTIVE: To compare the effects of two different A T P-sensitive potassium channel openers K R N2391 (K R N) and crokalin (C R) on isolated rat heart function and ischemic cardioprotection effect. Methods: The isolated hearts were subjected to complete ischemia for 25 minutes and the changes of cardiac function were observed at 30 minutes of reperfusion. Results: 1 ~ 20 μmol / L K R N and 1 ~ 20 μmol / L C R all significantly increased coronary perfusion. 20 μmol / L K R N and 10 μm ol / L C R significantly reduced cardiac contractile function, while 1 μmol / L K R N and 1 μmol / L C R both improved myocardial function after ischemia The role of this effect can be completely blocked by glyburide. Conclusion: The two drugs have obvious coronary dilatation, high-dose application can reduce cardiac contractile function, with no effect on cardiac function of both have a protective effect on the ischemic heart, this role with the A T P-sensitive potassium Channel open related.