【摘 要】
：
目的 探讨普拉洛芬滴眼液联合玻璃酸钠滴眼液对干眼症患者炎性因子水平的影响与安全性.方法 回顾性分析佛山市第五人民医院2019年5月至2020年5月收治的63例干眼症患者的临床资料,按照治疗方法的不同分为A组(30例)和B组(33例).A组患者采用玻璃酸钠滴眼液治疗,B组患者采用普拉洛芬滴眼液联合玻璃酸钠滴眼液治疗,两组患者均连续治疗4周.比较两组患者治疗总有效率,治疗前与治疗2、4周后泪液分泌实验(SIt)值、角膜荧光素染色(FL)评分,治疗前与治疗4周后炎性因子水平及治疗期间不良反应发生情况.结果 B组
【机 构】
：
佛山市第五人民医院眼科,广东 佛山 528211
论文部分内容阅读
目的 探讨普拉洛芬滴眼液联合玻璃酸钠滴眼液对干眼症患者炎性因子水平的影响与安全性.方法 回顾性分析佛山市第五人民医院2019年5月至2020年5月收治的63例干眼症患者的临床资料,按照治疗方法的不同分为A组(30例)和B组(33例).A组患者采用玻璃酸钠滴眼液治疗,B组患者采用普拉洛芬滴眼液联合玻璃酸钠滴眼液治疗,两组患者均连续治疗4周.比较两组患者治疗总有效率,治疗前与治疗2、4周后泪液分泌实验(SIt)值、角膜荧光素染色(FL)评分,治疗前与治疗4周后炎性因子水平及治疗期间不良反应发生情况.结果 B组患者治疗总有效率显著高于A组;治疗2、4周后两组患者SIt值均较治疗前显著升高,且B组显著高于A组;治疗2、4周后两组患者FL评分均较治疗前显著降低,且B组显著低于A组;治疗4周后两组患者血清白细胞介素-6(IL-6)、C-反应蛋白(CRP)水平均显著降低,且B组显著低于A组(均P0.05).结论 普拉洛芬滴眼液联合玻璃酸钠滴眼液可改善干眼症患者泪眼分泌,并促进角膜恢复,缓解局部炎症反应,且安全性良好.
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