最早报导接触术尘致鼻癌的是英国喉科专家Esma Hadfield,他发现该地20名鼻癌患者中,男性17名,其中有15名(88.2％)是制木椅的,接触木尘,8名女性患者未接触木尘而患鼻癌。1969年他又报导83名鼻肿瘤患者,其中23名腺癌,皆为男性,有15人住在High Wycombe,除2人外,余均接触木尘,该地鼻腺癌发病率约为60.1/百万/年,而在牛津地区医院为2.6～2.9/百万/年。以后,他又和Macbeth研究3100名家具工业工人,发现有64％的术工鼻粘膜有鳞状上皮化生,共他人仅占18％,他们认为鳞状上皮加厚增加了木尘在鼻内潴留,由于有刺激原存在或从尘粒中滤取其他活性 The earliest reported esophageal cancer caused by exposure to dust was Esma Hadfield, a British specialist in laryngology. He found that among the 20 patients with rhinosinusitis, 17 were male, of whom 15 (88.2%) were wooden chairs and were exposed to wood dust. Eight female patients developed nasal cancer without exposure to wood dust. In 1969 he again reported 83 patients with nasal tumors, of which 23 were adenocarcinomas, all men, 15 people live in High Wycombe, with the exception of two people, the other are exposed to wood dust, the incidence of nasal cancer is about 60.1 / Million / year, while in the Oxford area hospitals 2.6 ~ 2.9 / million / year. Later, he and Macbeth 3100 furniture industry workers and found that 64% of the surgical nose squamous metaplasia, a total of only 18% of others, they think the thickening of squamous epithelium increased dust in the nose Retention, due to the original stimulus or filter out other activities from the dust particles