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最近五年来,病毒化疗研究领域很活跃,有长足进展,尤其单纯疱疹病毒感染的化疗,已从实验阶段进入临床应用阶段。有人把目前的情况,比之四十年代末五十年代初细菌化疗的发展,是符合历史情况的。本文综述近三年的进展。一、和疱疹有关的病毒生物学单纯疱疹病毒(HSV)是有包膜的DNA病毒,双链DNA有17,000对碱基,控制50~+种病毒蛋白质的复制。近十年来HSV化疗制剂的品种渐增,其作用环节各异,化疗剂
In the recent five years, the research field of viral chemotherapy has been very active and has made great progress. In particular, the chemotherapy of herpes simplex virus infection has entered the clinical application stage from the experimental stage. Some people put the current situation, compared with the development of bacterial chemotherapy in the late 1940s and early 1950s, which is consistent with the historical situation. This article summarizes the progress of the past three years. Herpes Simplex Virus Herpes Simplex Virus (HSV) is an enveloped DNA virus that has 17,000 pairs of double-stranded DNA that controls the replication of 50+ viral proteins. Over the past decade, the variety of HSV chemotherapeutic agents has been gradually increasing, and its role in various aspects of chemotherapy drugs