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目的探讨髓母细胞瘤临床与预后的相关因素。方法回顾性分析经手术后病理学证实的73例髓母细胞瘤患者的肿瘤部位、肿瘤切除率、脑干侵袭程度、放疗、化疗、分流手术、胶质分化等相关因素对其预后的影响。73例患者中男48例,女25例,年龄平均13.6岁。并对55例患者进行了随访。结果在获取随访的55例患者中手术死亡6例,余49例平均生存时间为61个月,术后3年仍存活者20例,3年生存率为63.98%;术后5年仍存活者8例,5年生存率为43%,全脑-后颅-脊髓放疗患者较仅做全脑一后颅放疗的患者预后好。结论髓母细胞瘤患者的预后日前仍较差,手术切除后正规放疗及化疗有助于提高预后。
Objective To investigate the clinical and prognostic factors of medulloblastoma. Methods The prognosis of 73 patients with medulloblastoma confirmed by pathology were retrospectively analyzed. The tumor location, tumor resection rate, degree of brain stem invasion, radiotherapy, chemotherapy, shunt operation, glial differentiation and other related factors were retrospectively analyzed. There were 48 males and 25 females in 73 cases, with an average age of 13.6 years. 55 patients were followed up. Results Of the 55 patients who were followed up, 6 patients died of surgery, the remaining 49 patients had an average survival time of 61 months, 20 patients survived 3 years after operation and the 3-year survival rate was 63.98% Eight patients had a 5-year survival rate of 43%. Patients with whole-brain-posterior cranial-radiotherapy had better prognosis than those with posterior cranial radiotherapy alone. Conclusion The prognosis of patients with medulloblastoma is still poor recently, after surgery, regular radiotherapy and chemotherapy can help improve prognosis.