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目的:研究益生汤对小鼠免疫功能的调节作用。方法:BALB/C小鼠随机分为正常对照组、益生汤低剂量组(1.04 g·kg~(-1))、中剂量组(2.08 g·kg~(-1))和高剂量组(4.16 g·kg~(-1)),连续灌胃给药30 d,采用刀豆蛋白A诱导的小鼠脾T淋巴细胞转化实验、巨噬细胞的吞噬能力、NK细胞活性测定以及测定血清中IL-2研究益生汤对小鼠免疫功能的作用。结果:益生汤高、中、低剂量组均能明显增强巨噬细胞吞噬功能,增强小鼠脾脏T淋巴细胞的增殖转化反应,升高血清IL-2水平(P<0.05),中、高剂量组可使小鼠NK细胞活性明显升高(P<0.05或0.01)。结论:益生汤可明显增强小鼠的免疫功能。
Objective: To study the regulation effect of Yisheng Decoction on immune function in mice. Methods: BALB / C mice were randomly divided into normal control group, Yisheng Tang low dose group (1.04 g · kg -1), middle dose group (2.08 g · kg -1) and high dose group 4.16 g · kg ~ (-1)) were given intragastrically for 30 days. Concanavalin A induced splenic T lymphocyte transformation in mice, phagocytic activity of macrophages, NK cell activity, IL-2 study of the effect of Yisheng Decoction on immune function in mice. Results: Yisheng Decoction high, medium and low dose groups can significantly enhance phagocytic function of macrophages and enhance the proliferation and transformation of T lymphocytes in mice spleen, increased serum IL-2 levels (P <0.05), medium and high dose Group can significantly increase the activity of NK cells in mice (P <0.05 or 0.01). Conclusion: Yisheng Decoction can significantly enhance the immune function in mice.