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本研究选用尼莫地平 ＰＶＰ－ｋ３０固体分散体为原料，以羟丙基甲基纤维素（ＨＰＭＣ）为缓释材料，进行了尼莫地平缓释片剂处方的设计，考查其体外释药动力学，并对几种辅料及不同的制备方法对片剂释药情况的影响进行了研究。体外溶出度实验结果表明，在本实验范围内，尼莫地平由ＨＰＭＣ亲水性凝胶骨架片中的溶出过程更符合零级动力学。微晶纤维素的加入可使片剂释药速度加快，低粘度的羟乙基纤维素可使药物的溶出速率常数增加。将ＨＰＭＣ制成４０目颗粒后，再行压片，可使药物溶出度减慢。本研究筛选出的缓释片剂，可在１２小时内平稳释药。
In this study, nimodipine PVP-k30 solid dispersion as raw material, hydroxypropyl methylcellulose (HPMC) as sustained-release material, nimodipine sustained-release tablets prescription design, to test its in vitro release kinetics The effects of several excipients and different preparation methods on the release of tablets were studied. In vitro dissolution test results show that within the scope of this experiment, nimodipine by HPMC hydrophilic gel matrix piece dissolution process more in line with zero-order kinetics. The addition of microcrystalline cellulose can accelerate the release of tablets, and the low viscosity of hydroxyethyl cellulose can increase the dissolution rate constant of the drug. The HPMC made of 40 mesh particles, and then tableting, drug dissolution can slow down. The sustained-release tablets screened in this study can be smoothly released within 12 hours.