用扩增片段长度多态性技术分析短串联重复序列 (STR)基因座的DNA多态性 ,在山西地区汉族人群的CSF1PO基因座中发现 7个等位基因 ,19种基因型 ,群体调查证实该等位基因按孟德尔遗传规律遗传 ,观察的基因型分布符合Hardy -Weinberg定律 ,杂合度为 0 75。本研究显示 ,该基因座灵敏度高 ,易准确判型 ,是一较好遗传标记 ,适用于法医学、人类遗传学及临床医学等研究。 Amplified fragment length polymorphism was used to analyze the DNA polymorphism of short tandem repeat (STR) loci. Seven alleles and 19 genotypes were found in the locus CSF1PO of Han nationality in Shanxi Province. The population survey confirmed The allele was inherited according to Mendel’s genetic rule. The observed genotype distribution was in accordance with Hardy-Weinberg’s law with a heterozygosity of 0 75. This study shows that the locus is highly sensitive and accurate, and is a good genetic marker for forensic science, human genetics and clinical medicine research.