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目的:探讨甘露聚糖肽联合阿昔洛韦治疗单纯疱疹病毒性脑炎的临床疗效。方法:单纯疱疹病毒性脑炎患者68例,分为试验组和对照组,所有入选病例均给予常规治疗。同时试验组服用甘露聚糖肽胶囊+阿昔洛韦片,对照组服用匹多莫德胶囊+阿昔洛韦片,观察患者治疗前后临床症状、体征和免疫功能指标的变化。结果:试验组患者神经功能缺损评分显著下降,临床总有效率达91.18%,与对照组比较差异具有统计学意义(P<0.05)。试验组患者中性粒细胞、C3、IgA、IgG、IgM等指标较治疗前均有显著改善。两组治疗后NK、IgA、IgG等比较差异具有统计学意义(P<0.05),中性粒细胞、C3、IgM等比较差异具有统计学意义(P<0.01)。结论:甘露聚糖肽通过提高单纯疱疹病毒性脑炎患者机体免疫功能,增强抗病毒能力,有助于患者神经功能的恢复,提高临床疗效。
Objective: To investigate the clinical efficacy of mannan plus acyclovir in the treatment of herpes simplex virus encephalitis. Methods: Herpes simplex virus encephalitis in 68 patients, divided into experimental group and control group, all selected cases were given conventional treatment. At the same time, the experimental group took Mannatide capsules + acyclovir tablets, while the control group took pidotimod capsules + acyclovir tablets. The changes of clinical symptoms, signs and immune function before and after treatment were observed. Results: The score of neurological deficit in test group decreased significantly, the total clinical effective rate was 91.18%, which was significantly different from that in control group (P <0.05). The experimental group of neutrophils, C3, IgA, IgG, IgM and other indicators than before treatment were significantly improved. The difference of NK, IgA and IgG after treatment between the two groups was statistically significant (P <0.05). The difference of neutrophil, C3 and IgM was statistically significant (P <0.01). Conclusion: Mannan peptide can enhance the anti-virus ability of the patients with herpes simplex virus encephalitis, improve the recovery of neurological function and improve the clinical curative effect.