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体外实验提示前列腺素E(PGE)可以抑制免疫功能,推想PGE是肿瘤和创伤病人免疫功能抑制后的内源性产物,其半存留期极短,流经肺循环后即全部被代谢。为了测定在体内的真正作用,在9名健康志愿者(20～40岁)应用长效的PGE同类物,即口服米索前列醇(misoprostol)400μg,一日4次,共5天。在服药前后分别抽血30ml,测血浆各种氨基酸浓度、血清转铁蛋白、白蛋白、前白蛋白、白介素1、白介素6、肌酐、尿素氮、淋巴细胞亚属、淋巴
In vitro experiments suggest that prostaglandin E (PGE) can inhibit immune function, suggesting that PGE is an endogenous product of tumor suppression and traumatic immune suppression in patients with a very short half-life, that is, all through the pulmonary circulation metabolism. In order to determine the true role in the body, nine healthy volunteers (20-40 years old) were administered long lasting PGE congeners, ie 400 μg of misoprostol orally, 4 times a day for 5 days. Blood samples were taken before and after administration of 30ml plasma concentrations of various amino acids, serum transferrin, albumin, prealbumin, interleukin 1, interleukin 6, creatinine, urea nitrogen, lymphocyte subgenus, lymph