目的　研究大鼠胰腺促性腺激素释放激素 (Gn RH)受体 m RNA的存在及细胞定位 .方法　采用原位杂交组织化学法 .结果　胰脏的外分泌部腺上皮细胞、胰导管上皮细胞及内分泌部胰岛细胞内均可检测到较强的 Gn RH受体m RNA杂交信号 .杂交阳性信号物质均分布在胞质内 ,胞核呈阴性 .结论　大鼠胰脏内、外分泌部均能合成 Gn RH受体 .Gn RH也是一种消化激素 ,它由胰脏自身合成 ,又作用于胰脏 ,可能参与胰脏内、外分泌功能的调节 Objective To investigate the existence and cellular localization of m RNA of rat gonadotropin-releasing hormone (GnRH) receptor in rat.Methods In situ hybridization histochemistry was used to detect the expression of GnRH receptor mRNA in pancreatic glandular epithelial cells, pancreatic ductal epithelial cells and endocrine cells Gn RH receptor m RNA hybridization signal could be detected in islet cells.The hybridization positive signal substances were distributed in the cytoplasm and the nucleus was negative.Conclusion The Gn RH receptor Body. Gn RH is also a kind of digestive hormone, it is synthesized by the pancreas itself, but also on the pancreas, may be involved in the regulation of pancreatic exocrine function