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目的分析比较硝酸甘油与硝普钠治疗急性左心力衰竭的临床效果及安全性。方法本科室收治的64例急性左心力衰竭患者随机分为A组(n=32)和B组(n=32),用前瞻性随机实验法,A组患者硝酸甘油静脉给药,B组患者采用硝普钠静脉滴注治疗,对比两组的临床症状缓解情况及副作用发生率。结果①A组显效率34.3%(11/32)、有效率43.8%(14/32),总有效率78.1%;B组显效率59.4%(19/32)、有效率37.5%(12/32),总有效率为96.9%;两组的总有效率有显著差异(P<0.05);②两组的不良反应发生率无显著性差异(P>0.05)。结论硝普钠治疗急性左心力衰竭的临床效果显著,且不增加不良反应的发生率,值得临床推广普及。
Objective To compare the clinical efficacy and safety of nitroglycerin and sodium nitroprusside in the treatment of acute left heart failure. Methods Sixty-four patients with acute left heart failure admitted to our department were randomly divided into group A (n = 32) and group B (n = 32). The patients in group A were given intravenous nitroglycerin by prospective randomized trial. Patients in group B The use of sodium nitroprusside intravenous infusion treatment, compared the two groups of clinical symptoms and side effects of the incidence of remission. Results The effective rate of group A was 34.3% (11/32), the effective rate was 43.8% (14/32), the total effective rate was 78.1%. The effective rate of group B was 59.4% (19/32) and the effective rate was 37.5% (12/32) , And the total effective rate was 96.9%. The total effective rate was significantly different between the two groups (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Sodium nitroprusside treatment of acute left heart failure clinical effect is significant, and does not increase the incidence of adverse reactions, it is worth promoting clinical popularization.