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从1987年7月至1990年12月在上海市区及郊县36所医院进行出生缺陷与药物及化学物相关的病例对照调查研究。共收集缺陷病例组1,609例,对照组3,218例,经统计分析发现孕期服用APC、安定;母亲孕期接触农药、有机溶剂、苯、合成树脂和噪声;父亲接触有害物(化学物及物理因素)及吸烟>20支/天,与出生缺陷存在相关联系。同时也发现双亲家族遗传病史、母亲孕次≥2次,孕期营养差、感冒、肝炎、腹泻等亦与出生缺陷存在相关联系。
From July 1987 to December 1990 in Shanghai and suburban districts of 36 hospitals for birth defects and drug and chemical-related case-control study. A total of 1,609 cases of defective cases and 3,218 cases of control group were collected. Statistics showed that APC and diazepam were used during pregnancy. Maternal exposure to pesticides, organic solvents, benzene, synthetic resins and noise during the pregnancy; and fatalities (chemical substances and physical factors) Smoking> 20 cigarettes / day, associated with birth defects. At the same time also found that the genetic history of parents, parents of pregnancy ≥ 2 times, poor nutrition during pregnancy, colds, hepatitis, diarrhea, also associated with birth defects.