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目的探讨新诊断T2DM患者血清尿酸(SUA)水平的影响因素。方法选取新诊断T2DM患者490例,根据SUA水平分为合并高尿酸血症(T2DM+HUA)组67例和单纯T2DM组(T2DM组)323例。测定临床及相关生化指标,分析SUA升高的影响因素。结果 (1)新诊断T2DM患者高尿酸血症的患病率为13.67%(67/490),男性高于女性[9.80%(48/490)vs 3.88%(19/490),P=0.012];(2)T2DM+HUA组BMI、WC、谷丙转氨酶(ALT)、谷草转氨酶(AST)、TG、C-P、胰岛素抵抗指数(HOMA-IR)均高于T2DM组,年龄、HbA1c、HDL-C、ISI低于T2DM组(P<0.05);(3)多元线性回归分析显示,年龄、女性及HDL-C为SUA的保护性因素,2hC-P为SUA水平增高的危险因素。年龄是男性HUA的保护性因素,2hC-P为SUA水平增高的危险因素。HDL-C和ISI为女性HUA的保护性因素,脱酸脱氢酶(LDH)和2hC-P是女性HUA发生的危险因素。结论新诊断T2DM患者SUA水平受年龄、性别、肝功能、HDL-C及IS影响。
Objective To explore the influencing factors of serum uric acid (SUA) level in newly diagnosed T2DM patients. Methods 490 patients with newly diagnosed T2DM were selected and divided into SUA level according to SUA level: 67 cases with T2DM + HUA group and 323 cases with T2DM group (T2DM group). Determination of clinical and related biochemical indicators, analysis of the impact of elevated SUA. Results The prevalence of hyperuricemia in newly diagnosed T2DM patients was 13.67% (67/490), higher in males than in females [9.80% (48/490) vs 3.88% (19/490), P = 0.012] ; (2) The levels of BMI, WC, ALT, HOMA-IR, TG, CP and HOMA-IR in T2DM + HUA group were significantly higher than those in T2DM group (P <0.05). (3) Multivariate linear regression analysis showed that age, women and HDL-C were the protective factors of SUA, and 2hC-P was the risk factor of SUA. Age is a protective factor for male HUA, and 2hC-P is a risk factor for elevated SUA. HDL-C and ISI are protective factors for female HUA, and deacid dehydrogenase (LDH) and 2hC-P are risk factors for HUA in women. Conclusion SUA levels in newly diagnosed T2DM patients are affected by age, sex, liver function, HDL-C and IS.