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目的 :研究ERK1表达在胃癌发生中的作用。方法 :采用SABC免疫组织化学方法 ,检测 11例正常胃粘膜组织、2 3例胃癌组织、2 6例肠上皮化生及 2 1例不典型增生组织中ERK1的表达及分布。结果 :ERK1的表达在正常胃粘膜、肠上皮化生、不典型增生、胃癌组织中呈逐级递增的趋势 (P <0 0 1)。结论 :ERK1及其介导的信号通路的过度活化可能与胃癌的发生密切相关
Objective: To investigate the role of ERK1 expression in gastric carcinogenesis. Methods: The expression and distribution of ERK1 in 11 cases of normal gastric mucosa, 23 cases of gastric cancer, 26 cases of intestinal metaplasia and 21 cases of atypical hyperplasia were detected by SABC immunohistochemistry. Results: The expression of ERK1 was gradually increased in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma (P <0.01). Conclusion: The overactivation of ERK1 and its signal transduction pathway may be closely related to the occurrence of gastric cancer