目的 :探讨脑血管周围组织通道的功能。方法 :将大分子量的FITC标记的白蛋白(FA) ,及分子量相对较小的FITC标记右旋糖酐 (FD)分别定位注射入大鼠脑内 ,一定时间后通过示踪剂与血管同时显影的方法观察注入的荧光物质在脑内的分布情况及其与组织结构间的关系。结果 :注入FA、FD之后均可见微血管周围广泛分布荧光浓集细胞 (Mato细胞 ) ;FD在脑内扩散速度大于FA ;FA注入后还出现血管周围荧光浓集影像 ,并沿血管通向远处 ,在皮质者通向脑表面 ,在白质者通向脑腹侧颅底血管 ,速度与距离均大于简单扩散。结论 :脑血管周围组织通道与细胞间组织通道相比 ,具有物质传递优势 ;具有与淋巴管类似的功能 ,在大分子物质的传递引流方面具有重要作用 ;它与Mato细胞共同参与脑内免疫 Objective: To explore the function of cerebrovascular perivascular channel. Methods: FITC-labeled albumin (FA) with large molecular weight and FITC-labeled dextran (FD) with relatively small molecular weight were injected into the brain of rats, respectively. After a certain period of time, they were observed by simultaneous development of tracer and blood vessel Infusion of Fluorescent Material in Brain and Its Relationship with Tissue Structure. Results: After injection of FA and FD, all the macrophages around the distribution of fluorescence-rich cells (Mato cells); FD diffusion rate in the brain is greater than the FA; after FA injection also appeared around the peritubular fluorescence concentration of the image, , Leading to the brain surface in the cortex, white matter leading to the brain ventral skull base vessels, the speed and distance are greater than the simple proliferation. Conclusion: Compared with intercellular compartment, cerebrovascular perivascular channel has the advantage of mass transfer. It plays a similar role as lymphatic vessel and plays an important role in the transmission and drainage of macromolecules. It participates in intracerebral immunization with Mato cells