论文部分内容阅读
目的观察替吉奥(S-1)联合全脑放射治疗(WBRT)脑转移癌的近期疗效和不良反应。方法 50例脑转移瘤患者采用WBRT,30 Gy分10次,2周完成,同时口服替吉奥每天80 mg/m2,早晚2次餐后服用。放疗结束后3个月复查脑MRI。结果 50例患者的总有效率为80.0%,1年生存率为42.0%。主要不良反应为消化道反应、血液学毒性,多为Ⅰ～Ⅱ级。结论 S-1联合WBRT治疗脑转移瘤疗效确切,不良反应可耐受,能明显改善患者的生活质量。
Objective To observe the short-term curative effect and adverse reaction of brain-metastatic carcinoma of T-Gio (S-1) combined with whole brain radiation therapy (WBRT). Methods Fifty patients with brain metastases were treated with WBRT at 10 Gy for 10 weeks and completed at 2 weeks. At the same time, they were given 80 mg / m2 for tegazirin daily and taken after 2 meals in morning and evening. 3 months after the end of radiotherapy brain MRI review. Results The total effective rate of 50 patients was 80.0%, and the 1-year survival rate was 42.0%. The main adverse reactions of gastrointestinal reactions, hematological toxicity, mostly Ⅰ ~ Ⅱ grade. Conclusion S-1 combined with WBRT is effective in the treatment of brain metastases and can tolerate adverse reactions, and can significantly improve the quality of life of patients.