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采用酶免疫电泳印迹法检测了166例老年人的粪便及215例老年人的胃液,结果显示:MAbCOL-1所对应的抗原癌胚抗原(CEA)在老年人各组粪便、胃液中的阳性率分别为:胃癌70%、73%,萎缩性胃炎63%、67%,不典型增生67%、71%,浅表性胃炎及正常对照组全部为阴性。从而提示:MAbCOL-1不但在胃癌中有较高表达,而且早在癌前病变中就已有表达,而非癌前病变组及正常人全部为阴性,说明CEA的表达与胃癌的发生、发展密切相关,可作为早期胃癌诊断的参考指标,用于胃癌高危人群的普查。
Enzyme immunoelectrophoretic blot was used to detect the gastric juice in 166 elderly people and 215 elderly people. The results showed that the positive rate of CEA in the feces and gastric juice of each group of elderly patients was positive. They were: gastric cancer 70%, 73%, atrophic gastritis 63%, 67%, atypical hyperplasia 67%, 71%. Superficial gastritis and normal controls were all negative. This suggests that MAbCOL-1 is not only highly expressed in gastric cancer, but has been expressed early in precancerous lesions, but not in precancerous lesions and normal individuals, indicating the expression of CEA and the occurrence and development of gastric cancer. Closely related, can be used as a reference indicator for the diagnosis of early gastric cancer, for the general survey of high-risk groups of gastric cancer.