论文部分内容阅读
[目的]探讨朝鲜族SLC30A8,CDKN2A/B,HHEX和IRS-l等基因多态性与2型糖尿病(T2DM)的相关性及交互作用.[方法]用多因子降维法(MDR)分析313例朝鲜族T2DM患者及178例健康对照者的SLC30A8(rs13266634),CDKN2A/B(rs10811661),HHEX(rs7923837)和IRS-l(rs1801278)等基因多态性的交互作用.[结果]朝鲜族T2DM患者CDKN2A/B(rs10811661)基因的T等位基因频率与对照组比较差异有统计学意义(P<0.01).3位点rs13266634-rs10811661-rs7923837模型为最佳模型(P=0.000 3;Odd Ratio:2.063 2;95%CI:1.391 4~3.059 4),且交叉验证一致性系数最大(10/10).[结论]朝鲜族T2DM患者CDKN2A/B(rs10811661)基因的T等位基因可能与T2DM易感性相关.rs13266634,rs10811661,rs7923837基因位点之间可能存在基因-基因交互作用,rs13266634与rs7923837 2个SNP间的交互作用占主导地位.
[Objective] To investigate the correlation and interaction between Korean SLC30A8, CDKN2A / B, HHEX and IRS-1 gene polymorphisms and type 2 diabetes mellitus (T2DM). [Methods] (SNPs) of SLC30A8 (rs13266634), CDKN2A / B (rs10811661), HHEX (rs7923837) and IRS-1 (rs1801278) in Korean T2DM patients and 178 healthy controls. [Results] Korean T2DM The frequency of T allele in CDKN2A / B (rs10811661) gene was significantly higher than that in the control group (P <0.01), and the rs13266634-rs10811661-rs7923837 at the 3 locus was the best model (P = 0.0003; Odd Ratio : 2.063 2; 95% CI: 1.391 4 ~ 3.059 4), and the cross validation coefficient was the highest (10/10). [Conclusion] The T allele of CDKN2A / B (rs10811661) There was a possible gene-gene interaction between rs13266634, rs10811661 and rs7923837 loci, and the interaction between rs13266634 and rs7923837 was dominant.